Vonoprazan Fumarate CAS 881681-01-2

Cov tshuaj no yog qhia rau kev kho mob plab ulcers, duodenal ulcers, reflux esophagitis, erosive esophagitis, gastroesophageal reflux kab mob (GERD), Helicobacter pylori kab mob, thiab peptic ulcers.

Vonoprazan demonstrates acid stability and is rapidly absorbed when taken on an empty stomach, reaching peak plasma concentration (Cmax) within 1.5 to 2 hours after ingestion. It exhibits slow dissociation with a half-life of approximately 7.7 hours. Its high pKa value (>9) txhawb nqa nws cov tsub zuj zuj hauv qhov chaw luminal ntawm parietal cell canaliculi, kev sib tw inhibiting qhib thiab kaw ntawm lub twj tso kua mis proton. Peb kuj tuaj yeem muab N-1 CAS NO: 881674-56-2; CAS NO: 16133-25-8.

Yam khoom		Txuj kev cai	Kev Xeem
Qhov tshwm sim	Qhov tshwm sim	Dawb mus rau dawb dawb crystalline hmoov los yog crystalline hmoov	Off-dawb crystalline hmoov
Kev tsom xam	Fluorine check	3.9%-4.3%	4.2%
	Chlorides	Tsis ntau tshaj 0.05%	Ua raws
	Ammonium ntsev	Tsis ntau tshaj 0.05%	Ua raws
	Sulfate	Tsis ntau tshaj 0.05%	Ua raws
	Dej	Tsis ntau tshaj 0.40%	Ua raws
	Residue ntawm Ignition	Tsis ntau tshaj 0.10%	0.021%
	Cov hlau hnyav	Tsis ntau tshaj 20 ppm	Ua raws
	Organic impurities	Ib qho impurity: tsis ntau tshaj 0.15%	0.062%
		Tag nrho impurity: tsis ntau tshaj 1.0%	0.25%
	Residual Solvents	Methanol: tsis ntau tshaj 0.30%	Tsis pom
		Ethanol: tsis ntau tshaj 0.50%	Tsis pom
		Ethyl acetate: tsis ntau tshaj 0.50%	Tsis pom
		Dichloromethane: tsis ntau tshaj 0.060%	Tsis pom
		Acetonitrile: tsis ntau tshaj 0.041%	Tsis pom
		Tetrahydrofuran: tsis ntau tshaj 0.072%	Tsis pom
		Benzene: tsis moare tshaj 0.020%	Tsis pom
		Pyridine: tsis ntau tshaj 0.020%	Tsis pom
		N, N-Dimethylacetamide: tsis ntau tshaj 0.10%	Tsis pom
		Methylamine: tsis ntau tshaj 0.10%	Tsis pom
		Acetic acid: tsis ntau tshaj 0.50%	Tsis pom
Cov ntsiab lus ntawm Fumaric acid		23.9%-26.4%	24.5%
Assay		NLT 98.0% thiab NMT 102.0% ntawm C17H16FN3O2S.C4H4O4, xam nyob rau hauv lub hauv paus anhydrous	99.2%

Vonoprazan Fumarate CAS 881681-01-2

Khoom: Vonoprazan Fumarate CAS 881681-01-2
Lub npe tshuaj: 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl )-N-methylmethanamine fumarate
Lwm lub npe: TAK438; TAK-438; MFCD18633280; 1260141-27-2 TAK-438 AKSci J97352; Fumarat Vonoprazana; Vonoprasan Fumarate-D3; N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methanamine; 1-(5-(2-Fluorophenyl); AB457904 CAS 881681-01-2;
CAS Nr.: 881681-01-2
Khoom Qeb: Gastrointestinal API, Pepsin digestive enzyme API, Pancreatin digestive enzyme API
Molecular Luj: 461.46300
Molecular Formula: C₂₁H₂₀FN₃O₆S
MDL No.: MFCD18633280

 

1. Lub sijhawm them nyiaj

TT, LC

2. Hnub xa khoom

Sib tham tau

3. Kev ua lag luam

Middle East / Africa / Asia / South America / Europe

4. Qauv:

Muaj
5. Cov qauv kev tswj hwm
PIB, EP, IP

6. Daim ntawv pov thawj
Kev tso npe "A" raws li txoj cai ntawm cov khoom ntim ntim, Kev Ceeb Toom Kev Pom Zoo ntawm kev lag luam daim ntawv thov rau chemical API, WC, COPP, CEP, EUGMP, US DMF tus lej sau npe, Is Nrias teb daim ntawv pov thawj, npe Brazil, npe Malaysia, thiab lwm yam.

7. Packing size specification

Pem hauv ntej pob: ib txheej polyethylene hnab thiab txhuas ntawv ci hnab.

Sab nrauv pob: fiber nruas.

Ntim loj: 20 kg / nruas; 1 kg / nruas; 5kg / nruas.

Vonoprazan fumarate (TAK-438) muaj ntau yam txiaj ntsig raws li proton twj tso kua mis inhibitor (PPI) rau kev kho mob ntawm cov kua qaub ntsig txog plab hnyuv. Qee qhov txiaj ntsig suav nrog:

1. Muaj peev xwm thiab nrawm nrawm nrawm: Vonoprasan muab lub zog thiab nrawm inhibition ntawm gastric acid secretion. Nws ua haujlwm zoo thaiv H+/K+-ATPase enzyme, ua rau txo qis hauv plab acid ntau lawm. Qhov kev tiv thaiv muaj zog acid no tuaj yeem ua rau cov tsos mob sai sai thiab txhim kho cov kab mob plab hnyuv thiab kev puas tsuaj rau esophageal.

2. Lub Sijhawm Ua Haujlwm ntev dua: Vonoprasan muaj lub sijhawm ua haujlwm ntev dua piv rau PPIs ib txwm muaj. Nws tswj cov kua qaub zoo rau lub sijhawm ntev, tso cai rau noj ib hnub ib zaug. Qhov yooj yim no tuaj yeem txhim kho tus neeg mob ua raws li kev kho mob.

3. Txhim kho kev tswj ntawm Nocturnal Acid Breakthrough: Nocturnal acid breakthrough yog hais txog qhov rov tshwm sim ntawm gastric acid secretion thaum hmo ntuj, uas tuaj yeem cuam tshuam kev pw tsaug zog thiab ua rau cov tsos mob hnyav dua. Vonoprazan tau ua kom pom kev tswj hwm zoo ntawm cov kua qaub nocturnal breakthrough piv rau lwm cov PPIs, ua kom cov kua qaub zoo dua thaum hmo ntuj.

4. Txhim kho cov kab mob plab hnyuv: Vonoprazan txhawb kev kho mob ntawm plab hnyuv thiab duodenal rwj los ntawm kev txo cov kua qaub thiab tsim kom muaj qhov chaw zoo rau kev kho cov ntaub so ntswg. Cov kev tshawb fawb tau pom tias vonoprasan ua tiav cov txiaj ntsig kho tau zoo dua piv rau PPIs ib txwm muaj, ua rau muaj kev daws teeb meem sai dua ntawm cov kab mob.

5. Muaj peev xwm rau Refractory Acid-Related Disorders: Vonoprazan tej zaum yuav muaj txiaj ntsig zoo rau cov neeg mob refractory acid-related disorders, suav nrog cov neeg uas tsis teb txaus rau cov qauv PPI kho. Nws muaj zog acid-suppressing zog ua rau nws muaj txiaj ntsig zoo rau cov tib neeg uas xav tau kev tswj xyuas cov kua qaub ntau dua.

6. Txo kev pheej hmoo ntawm kev cuam tshuam tshuaj yeeb: Vonoprasan muaj peev xwm txo qis rau kev cuam tshuam tshuaj yeeb tshuaj piv rau qee qhov PPIs. Nws tsis tshua muaj kev cuam tshuam nrog cov metabolism ntawm qee yam tshuaj, txo qhov kev pheej hmoo ntawm kev phiv los yog cuam tshuam kev kho mob.

Peb muaj cov chaw ua haujlwm hauv Dubai thiab Is Nrias teb

peb muaj tus kheej txhim khu kev qha & Kev koom tes ntev & kev paub txog lub Hoobkas

Ntau yam khoom rau xaiv los ntawm Tuam Tshoj thiab Is Nrias teb

Peb tuaj yeem kho raws li koj xav tau

Peb tuaj yeem ua OEM & ODM

Peb tuaj yeem muab N-1 rau API

Cim npe nrov: Vonoprazan fumarate cas 881681-01-2, Tuam Tshoj vonoprasan fumarate cas 881681-01-2 tuam ntxhab, lwm tus neeg, Hoobkas